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Randomised Study of Antiepileptic Drug Withdrawal in Patients in Remission Med Res Council AED Withdrawal Study Group, Lancet 337:1175-1180, 1193-1194991., , 1991 See this aricle in Pubmed Article Abstract A prospective multicentre randomised study of continued antiepileptic treatment vs slow withdrawal was conducted in 1013 patients who had been free of seizures for at least 2 years.Comparison of randomised and eligible,but non-randomised,patients suggests the results should be applicable to a wider patient population.By 2 years after randomisation, 78%of patients in whom treatment was continued and 59%of those in whom it was withdrawn remained seizure free,but thereafter the differences between the two groups diminished.Non-compliance with continued treatment accounted for only a small proportion of the risk to the group continuing with treatment.The most important factors determining outcome were longer seizure-free periods(reducing the risk)and more than one antiepileptic drug and a history of tonic-clonic seizures(increasing the risk).Other factors(eg,history of neonatal seizures,specific electroencephalographic features)seemed to have smaller effects,but even in such a large study the confidence intervals for these observations were wide.

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(click to filter results - removes previous filter) anticonvulsants anticonvulsants,discontinuation in seizure-free epileptics seizure seizure,prognosis in adults seizure,prognosis in childhood seizure,treatment of

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